Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells
نویسندگان
چکیده
منابع مشابه
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells
HIV-infected individuals currently cannot be completely cured because existing antiviral therapy regimens do not address HIV provirus DNA, flanked by long terminal repeats (LTRs), already integrated into host genome. Here, we present a possible alternative therapeutic approach to specifically and directly mediate deletion of the integrated full-length HIV provirus from infected and latently inf...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2018
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2018.04.014